diff --git a/src/flake8/utils.py b/src/flake8/utils.py
index 4eb6537..a4c67ce 100644
--- a/src/flake8/utils.py
+++ b/src/flake8/utils.py
@@ -29,7 +29,8 @@ def parse_comma_separated_list(value):
     if not isinstance(value, (list, tuple)):
         value = value.split(',')
 
-    return [item.strip() for item in value]
+    item_gen = (item.strip() for item in value)
+    return [item for item in item_gen if item]
 
 
 def normalize_paths(paths, parent=os.curdir):
diff --git a/tests/unit/test_utils.py b/tests/unit/test_utils.py
index 79d83cf..0a12f2d 100644
--- a/tests/unit/test_utils.py
+++ b/tests/unit/test_utils.py
@@ -13,8 +13,13 @@ RELATIVE_PATHS = ["flake8", "pep8", "pyflakes", "mccabe"]
 @pytest.mark.parametrize("value,expected", [
     ("E123,\n\tW234,\n    E206", ["E123", "W234", "E206"]),
     ("E123,W234,E206", ["E123", "W234", "E206"]),
+    ("E123,W234,E206,", ["E123", "W234", "E206"]),
+    ("E123,W234,,E206,,", ["E123", "W234", "E206"]),
+    ("E123,,W234,,E206,,", ["E123", "W234", "E206"]),
     (["E123", "W234", "E206"], ["E123", "W234", "E206"]),
     (["E123", "\n\tW234", "\n    E206"], ["E123", "W234", "E206"]),
+    (["E123", "\n\tW234", "\n    E206", "\n"], ["E123", "W234", "E206"]),
+    (["E123", "\n\tW234", "", "\n    E206", "\n"], ["E123", "W234", "E206"]),
 ])
 def test_parse_comma_separated_list(value, expected):
     """Verify that similar inputs produce identical outputs."""