diff --git a/docs/source/internal/start-to-finish.rst b/docs/source/internal/start-to-finish.rst
index faed9bd..5e31083 100644
--- a/docs/source/internal/start-to-finish.rst
+++ b/docs/source/internal/start-to-finish.rst
@@ -47,21 +47,6 @@ both cases, however, you end up in :func:`flake8.main.cli.main`. This is the
 primary way that users will end up starting Flake8. This function creates an
 instance of |Application|.
 
-via Setuptools
---------------
-
-If you're invoking |Flake8| from your ``setup.py`` then you actually end up in
-:meth:`flake8.main.setuptools_command.Flake8.run`. This then collects the
-files that are included in the package information and creates an instance of
-|Application|.
-
-via Git or Mercurial
---------------------
-
-In both cases, they call their respective ``hook`` functions which create
-instances of |Application|.
-
-
 Application Logic
 =================
 
diff --git a/docs/source/user/index.rst b/docs/source/user/index.rst
index 5a24b21..90d5b14 100644
--- a/docs/source/user/index.rst
+++ b/docs/source/user/index.rst
@@ -8,8 +8,6 @@
 
 - invoked via Python
 
-- called by Git or Mercurial on or around committing
-
 This guide will cover all of these and the nuances for using |Flake8|.
 
 .. note::
diff --git a/setup.cfg b/setup.cfg
index 0d3ab08..9103522 100644
--- a/setup.cfg
+++ b/setup.cfg
@@ -56,8 +56,6 @@ python_requires = >=2.7, !=3.0.*, !=3.1.*, !=3.2.*, !=3.3.*, !=3.4.*
 where = src
 
 [options.entry_points]
-distutils.commands=
-    flake8 = flake8.main.setuptools_command:Flake8
 console_scripts =
     flake8 = flake8.main.cli:main
 flake8.extension =
diff --git a/src/flake8/main/setuptools_command.py b/src/flake8/main/setuptools_command.py
deleted file mode 100644
index fde290e..0000000
--- a/src/flake8/main/setuptools_command.py
+++ /dev/null
@@ -1,115 +0,0 @@
-"""The logic for Flake8's integration with setuptools."""
-from distutils import log
-import os
-from typing import List, Tuple
-
-import setuptools
-
-from flake8.main import application as app
-
-UNSET = object()
-
-
-class Flake8(setuptools.Command):
-    """Run Flake8 via setuptools/distutils for registered modules."""
-
-    description = "Run Flake8 on modules registered in setup.py"
-    # NOTE(sigmavirus24): If we populated this with a list of tuples, users
-    # could do something like ``python setup.py flake8 --ignore=E123,E234``
-    # but we would have to redefine it and we can't define it dynamically.
-    # Since I refuse to copy-and-paste the options here or maintain two lists
-    # of options, and since this will break when users use plugins that
-    # provide command-line options, we are leaving this empty. If users want
-    # to configure this command, they can do so through config files.
-    user_options = []  # type: List[str]
-
-    def initialize_options(self):
-        """Override this method to initialize our application."""
-        self.flake8 = app.Application()
-        self.flake8.initialize([])
-        options = self.flake8.option_manager.options
-        for option in options:
-            if option.parse_from_config:
-                setattr(self, option.config_name, UNSET)
-
-    def finalize_options(self):
-        """Override this to parse the parameters."""
-        options = self.flake8.option_manager.options
-        for option in options:
-            if option.parse_from_config:
-                name = option.config_name
-                value = getattr(self, name, UNSET)
-                if value is UNSET:
-                    continue
-                setattr(
-                    self.flake8.options,
-                    name,
-                    option.normalize_from_setuptools(value),
-                )
-
-    def package_files(self):
-        """Collect the files/dirs included in the registered modules."""
-        seen_package_directories = ()  # type: Tuple[str, ...]
-        directories = self.distribution.package_dir or {}
-        empty_directory_exists = "" in directories
-        packages = self.distribution.packages or []
-        for package in packages:
-            package_directory = package
-            if package in directories:
-                package_directory = directories[package]
-            elif empty_directory_exists:
-                package_directory = os.path.join(
-                    directories[""], package_directory
-                )
-
-            # NOTE(sigmavirus24): Do not collect submodules, e.g.,
-            # if we have:
-            #  - flake8/
-            #  - flake8/plugins/
-            # Flake8 only needs ``flake8/`` to be provided. It will
-            # recurse on its own.
-            if package_directory.startswith(seen_package_directories):
-                continue
-
-            seen_package_directories += (package_directory + ".",)
-            yield package_directory
-
-    def module_files(self):
-        """Collect the files listed as py_modules."""
-        modules = self.distribution.py_modules or []
-        filename_from = "{0}.py".format
-        for module in modules:
-            yield filename_from(module)
-
-    def distribution_files(self):
-        """Collect package and module files."""
-        for package in self.package_files():
-            yield package
-
-        for module in self.module_files():
-            yield module
-
-        yield "setup.py"
-
-    def run(self):
-        """Run the Flake8 application."""
-        self.flake8.run_checks(list(self.distribution_files()))
-        self.flake8.formatter.start()
-        self.flake8.report_errors()
-        self.flake8.report_statistics()
-        self.flake8.report_benchmarks()
-        self.flake8.formatter.stop()
-        try:
-            self.flake8.exit()
-        except SystemExit as e:
-            # Cause system exit only if exit code is not zero (terminates
-            # other possibly remaining/pending setuptools commands).
-            if e.code:
-                raise
-        finally:
-            self.announce(
-                "WARNING: flake8 setuptools integration is deprecated and "
-                "scheduled for removal in 4.x.  For more information, see "
-                "https://gitlab.com/pycqa/flake8/issues/544",
-                log.WARN,
-            )
diff --git a/tests/unit/test_setuptools_command.py b/tests/unit/test_setuptools_command.py
deleted file mode 100644
index 1c52b2a..0000000
--- a/tests/unit/test_setuptools_command.py
+++ /dev/null
@@ -1,33 +0,0 @@
-"""Module containing tests for the setuptools command integration."""
-import pytest
-from setuptools import dist
-
-from flake8.main import setuptools_command
-
-
-@pytest.fixture
-def distribution():
-    """Create a setuptools Distribution object."""
-    return dist.Distribution({
-        'name': 'foo',
-        'packages': [
-            'foo',
-            'foo.bar',
-            'foo_biz',
-        ],
-    })
-
-
-@pytest.fixture
-def command(distribution):
-    """Create an instance of Flake8's setuptools command."""
-    return setuptools_command.Flake8(distribution)
-
-
-def test_package_files_removes_submodules(command):
-    """Verify that we collect all package files."""
-    package_files = list(command.package_files())
-    assert sorted(package_files) == [
-        'foo',
-        'foo_biz',
-    ]